The deaths of three people are under investigation in connection with the NHS 111 non-emergency phone line, according to a report.
The general practitioners trade magazine Pulse reported that at least 22 possible "serious untoward incidents" (or SUIs) related to NHS 111 have been reported since the launch of the service.
Those incidents included three where a patient died, the magazine has claimed.
Two of the deaths occurred in the East Midlands, and one in the West Midlands.
The deaths reportedly include the case of a 47-year-old who died from a suspected overdose.
That death occurred after relatives contacted NHS 111 requesting mental health assistance, Pulse reported.
A further 19 possible SUIs have been recorded by providers or commissioners, the magazine added.
Rolled out across most of the country last month, the NHS 111 service is for people urgently seeking medical help or advice but who are not in a life-threatening situation.
The service was introduced to replace NHS Direct in England and is meant to ease pressure on emergency 999 call centres.
NHS England said it could not verify the data reported in Pulse, however it issued a statement in response to the magazine's report.
"The safety of patients must be our paramount concern and NHS England will keep a careful eye on the situation to ensure NHS 111 provides not only a good service to the public, but one which is also safe," the statement read.
Earlier this week, NHS England announced a review of the 111 service.
A spokesman said: "The performance standards which have been introduced for NHS 111 represent a gold standard which the majority of NHS 111 services in England are now meeting, though in some areas performance is still unacceptable, especially at weekends.
"Some local providers of NHS 111 have not provided the prompt, reliable service the public need and want.
"NHS England's board is determined to ensure that the public have access to a gold standard NHS 111 service wherever they live in England."
But Clare Gerada, chairwoman of the Royal College of General Practitioners, raised concerns about the free-to-call advice line.
"It is extremely worrying that there is still so much uncertainty around the delivery and reliability of the advice provided by NHS 111 in some areas.
"We are also concerned that patients are losing confidence in the new service before it is even fully up and running.
"We call on NHS England to provide more reassurance about its effectiveness and ability to deliver the necessary standards of care for all patients using the service, right across England."
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