The parents of Ashya King, who was taken out of hospital against medical advice, have been arrested after being found with their son in Spain.
Police say officers in the Malaga area pulled over the family's car at 9pm UK time and found the five-year-old and his parents inside.
The boy from Portsmouth, who underwent "extensive surgery" during an operation on his brain tumour seven days ago, has been taken to hospital.
Assistant Chief Constable Chris Shead of Hampshire Constabulary said his parents, Brett King, 51, and Naghemeh King, 45, were in custody after being arrested on a European arrest warrant.
"We don't have many details on Ashya's condition at this point in time but what we do know is that he was showing no visible signs of distress," he said.
"There are no winners in this situation. I've said all along that this must be a terribly distressing time for Ashya's family and I stand by that now."
He added that it was too soon to say when Ashya would come back to the UK but said Southampton General Hospital had been contacted so they can liaise with doctors taking care of him in Spain.
"Ashya's brothers and sisters were not in the vehicle," he said.
"We have located them. They're all okay, they're fine. They are actually in a hotel about 10 miles away."
He said a team of Hampshire police officers would now be travelling to Spain to continue the investigation.
French media had picked up the story after Ashya was taken from hospital It came as footage emerged on video-sharing website YouTube in which Ashya's father, a Jehovah's Witness, insists they had taken him from hospital to seek a cancer treatment not available on the NHS.
"We were much disturbed today to find that his face is all over the internet and newspapers and we've been labelled as kidnappers, putting his life at risk, neglect," he says.
"There's been a lot of talk about this machine. As you see, it's all plugged in. We've got loads of these feeds here, we've got iron supplements and we've got Calpol.
"As you can see, there's nothing wrong with him. He's very happy actually, since we took him out of hospital. He's been smiling a lot more, he's been very much interacting with us.
"But I just wanted to say very quickly why we took him out of the hospital.
"The surgeon did a wonderful job on his head that took out the brain tumour, completely they reckon. But straight away afterwards he went into what's called posterior fossa syndrome, which means very limited moving or talking or doing anything."
He said he had spoken to specialists after Ashya's surgery and had requested proton beam treatment, which was not available on the NHS.
"Proton beam is so much better for children with brain cancer," he said.
"We pleaded with them for proton beam treatment. They looked at me straight in the face and said with his cancer - which is called medulloblastoma - it would have no benefit whatsoever.
"I went straight back to my room and looked it up and the American sites and French sites and Switzerland sites where they have proton beam said the opposite, it would be very beneficial for him."
Mr King also urged police to call off "this ridiculous chase".
"We're not neglecting our son, he's in perfectly good health," he said.
Jehovah's Witnesses refuse blood transfusions on religious grounds but are open to other medical procedures.
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